View Filing Data

Document and Entity Information - shares	6 Months Ended
Document and Entity Information - shares	Jun. 30, 2017	Aug. 01, 2017
Document and Entity Information
Entity Registrant Name	IMMUNOGEN INC
Entity Central Index Key	0000855654
Document Type	10-Q
Document Period End Date	Jun. 30, 2017
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Current Reporting Status	Yes
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		89,597,770
Document Fiscal Year Focus	2017
Document Fiscal Period Focus	Q2

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
ASSETS
Cash and cash equivalents	$ 150,337	$ 159,964
Accounts receivable	1,024	2,026
Unbilled revenue	1,807	6,778
Inventory	3,482	2,192
Prepaid and other current assets	4,758	5,386
Total current assets	161,408	176,346
Property and equipment, net of accumulated depreciation	16,821	19,498
Other assets	3,148	3,020
Total assets	181,377	198,864
LIABILITIES AND SHAREHOLDERS' DEFICIT
Accounts payable	5,152	7,895
Accrued compensation	7,212	6,946
Other accrued liabilities	12,332	11,150
Current portion of deferred lease incentive	784	784
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $812 and $850, respectively	15,678	14,470
Current portion of deferred revenue	26,192	14,531
Total current liabilities	67,350	55,776
Deferred lease incentive, net of current portion	5,521	5,914
Deferred revenue, net of current portion	18,912	19,086
Convertible 4.5% senior notes, net of deferred financing costs of $2,701 and $3,035, respectively	97,299	96,965
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $2,750 and $3,144, respectively	161,339	169,858
Other long-term liabilities	4,185	4,115
Total liabilities	354,606	351,714
Commitments and contingencies (Note H)
Shareholders' deficit:
Preferred stock, $0.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 150,000 shares; issued and outstanding 89,597 and 87,301 shares as of June 30, 2017 and December 31, 2016, respectively	896	873
Additional paid-in capital	784,657	778,847
Accumulated deficit	(958,782)	(932,570)
Total shareholders’ deficit	(173,229)	(152,850)
Total liabilities and shareholders’ deficit	$ 181,377	$ 198,864

CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016
CONSOLIDATED BALANCE SHEETS
Current portion of deferred financing costs for the liability related to the sale of future royalties	$ 812	$ 850
Interest rate (as a percent)	4.50%
Non-current deferred financing costs	$ 2,701	3,035
Noncurrent portion of deferred financing costs for the liability related to the sale of future royalties	$ 2,750	$ 3,144
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, authorized shares	5,000	5,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, authorized shares	150,000,000	150,000,000
Common stock, issued shares	89,597,000	87,301,000
Common stock, outstanding shares	89,597,000	87,301,000

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
License and milestone fees	$ 31,080	$ 76	$ 49,810	$ 10,153
Non-cash royalty revenue related to the sale of future royalties	6,439	5,944	14,052	13,324
Research and development support	902	1,335	2,380	2,394
Clinical materials revenue	599	53	1,277	1,251
Total revenues	39,020	7,408	67,519	27,122
Operating Expenses:
Research and development	35,319	38,652	68,207	74,746
General and administrative	8,836	9,298	16,955	20,533
Restructuring charges			386
Total operating expenses	44,155	47,950	85,548	95,279
Loss from operations	(5,135)	(40,542)	(18,029)	(68,157)
Investment income, net	143	106	258	214
Non-cash interest expense on liability related to the sale of future royalties and convertible senior notes	(3,501)	(4,956)	(7,076)	(9,928)
Interest expense on convertible senior notes	(1,125)	(138)	(2,250)	(138)
Other income, net	751	(392)	885	159
Net loss	$ (8,867)	$ (45,922)	$ (26,212)	$ (77,850)
Basic and diluted net loss per common share (in dollar per share)	$ (0.10)	$ (0.53)	$ (0.30)	$ (0.89)
Basic and diluted weighted average common shares outstanding (in shares)	87,174	87,062	87,167	87,029
Total comprehensive loss	$ (8,867)	$ (45,922)	$ (26,212)	$ (77,850)

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Cash flows from operating activities:
Net loss	$ (26,212)	$ (77,850)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(14,052)	(13,324)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	7,076	9,928
Depreciation and amortization	2,934	2,940
Loss on sale/disposal of fixed assets and impairment charges	180	5
Stock and deferred share unit compensation	5,801	11,862
Deferred rent	49	105
Change in operating assets and liabilities:
Accounts receivable	1,002	(80)
Unbilled revenue	4,971	(524)
Inventory	(1,290)	630
Prepaid and other current assets	628	1,737
Other assets	(128)	(487)
Accounts payable	(2,394)	(525)
Accrued compensation	266	5,269
Other accrued liabilities	802	1,900
Deferred revenue	11,487	(716)
Proceeds from landlord for tenant improvements		144
Net cash used for operating activities	(8,880)	(58,986)
Cash flows from investing activities:
Purchases of property and equipment	(779)	(5,249)
Net cash used for investing activities	(779)	(5,249)
Cash flows from financing activities:
Proceeds from stock options exercised	32	370
Proceeds from issuance of convertible 4.5% notes, net of $3,392 of transaction costs		96,608
Net cash provided by financing activities	32	96,978
Net change in cash and cash equivalents	(9,627)	32,743
Cash and cash equivalents, beginning balance	159,964	212,283
Cash and cash equivalents, ending balance	$ 150,337	$ 245,026

CONSOLIDATED STATEMENTS OF CASH FLOWS (Parenthetical) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2016	Jun. 30, 2017
CONSOLIDATED STATEMENTS OF CASH FLOWS
Interest rate (as a percent)	4.50%	4.50%
Issuance of debt transaction costs	$ 3,392

Nature of Business and Plan of Operations	6 Months Ended
Nature of Business and Plan of Operations	Jun. 30, 2017
Nature of Business and Plan of Operations
Nature of Business and Plan of Operations	IMMUNOGEN, INC. NOTES TO CONSOLIDATED FINANCIAL STATEMENTS June 30, 2017 A.Nature of Business and Plan of Operations ImmunoGen, Inc. (the Company) was incorporated in Massachusetts in 1981 and is focused on the development of antibody-drug conjugates, or ADCs, for the treatment of cancer. In August 2014, the FASB issued ASU 2014‑15, Presentation of Financial Statements-Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern. (ASU 2015-14). Under the new standard, management must evaluate whether there are conditions or events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that the financial statements are issued. This evaluation initially does not take into consideration the potential mitigating effect of management’s plans that have not been fully implemented as of the date the financial statements are issued. When substantial doubt exists under this methodology, management evaluates whether the mitigating effect of its plans sufficiently alleviates substantial doubt about the Company’s ability to continue as a going concern. The mitigating effect of management’s plans, however, is only considered if both (1) it is probable that the plans will be effectively implemented within one year after the date that the financial statements are issued, and (2) it is probable that the plans, when implemented, will mitigate the relevant conditions or events that raise substantial doubt about the entity’s ability to continue as a going concern within one year after the date that the financial statements are issued. Generally, to be considered probable of being effectively implemented, the plans must have been approved before the date that the financial statements are issued. This standard was adopted by the Company at December 31, 2016. The Company has incurred operating losses and negative cash flows from operations since inception, incurred a net loss of approximately $26.2 million during the six months ended June 30, 2017, and has an accumulated deficit of approximately $958.8 million as of June 30, 2017. The Company has primarily funded these losses through payments received from its collaborations and equity and convertible debt financings. To date, the Company has no product revenue and management expects operating losses to continue for the foreseeable future. At June 30, 2017, the Company had $150.3 million of cash and cash equivalents on hand. The Company anticipates that its current capital resources and expected future collaborator payments will enable it to meet its operational expenses and capital expenditures (operating plan) into the third quarter of calendar year 2018. Without such collaborator payments, the Company’s existing capital resources at June 30, 2017 would not be sufficient to support the current operating plan through August 4, 2018, which is twelve months after the date that the June 2017 financial statements were issued. Management expects to seek additional funds from collaboration partners through a combination of upfront license payments, milestone payments, royalty payments, research funding, and clinical material reimbursement or from equity or debt financings. Because those plans have not been finalized, receipt of additional funding is not considered probable under the new standard. If the Company does not obtain sufficient funds when needed, the Company expects it would scale back its operating plan by deferring or limiting some or all of its research, development or clinical projects, or initiate further reductions to its workforce. Because such contingency plans have not been finalized (because the specifics would depend on the situation at the time), such actions also are not considered probable for purposes of the new standard. Because, under the new standard, neither receipt of future collaboration payments, nor management’s contingency plans to mitigate the risk and extend cash resources through August 4, 2018, are considered probable, substantial doubt is deemed to exist about the Company’s ability to continue as a going concern. The Company is subject to risks common to companies in the biotechnology industry including, but not limited to, the development by its competitors of new technological innovations, dependence on key personnel, protection of proprietary technology, manufacturing and marketing limitations, collaboration arrangements, third‑party reimbursements and compliance with governmental regulations.

Summary of Significant Accounting Policies

6 Months Ended

Jun. 30, 2017

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies

B.Summary of Significant Accounting Policies

Basis of Presentation

The accompanying unaudited consolidated financial statements at June 30, 2017 and December 31, 2016 and for the three and six months ended June 30, 2017 and 2016 include the accounts of ImmunoGen, Inc., or the Company, and its wholly owned subsidiaries, ImmunoGen Securities Corp., ImmunoGen Europe Limited and Hurricane, LLC. The consolidated financial statements include all of the adjustments, consisting only of normal recurring adjustments, which management considers necessary for a fair presentation of the Company’s financial position in accordance with accounting principles generally accepted in the U.S. for interim financial information. The December 31, 2016 condensed consolidated balance sheet data presented for comparative purposes was derived from our audited financial statements but certain information and footnote disclosures normally included in the Company’s annual financial statements have been condensed or omitted. The preparation of interim financial statements requires the use of management’s estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the interim financial statements and the reported amounts of revenues and expenditures during the reported periods. The results of the interim periods are not necessarily indicative of the results for the entire year. Accordingly, the interim financial statements should be read in conjunction with the audited financial statements and notes thereto included in the Company’s Transition Report on Form 10-K for the six months ended December 31, 2016.

Subsequent Events

The Company has evaluated all events or transactions that occurred after June 30, 2017 up through the date the Company issued these financial statements. The Company did not have any material recognizable or unrecognizable subsequent events during this period.

Revenue Recognition

The Company enters into licensing and development agreements with collaborative partners for the development of ADC therapeutics. The terms of these agreements contain multiple deliverables which may include (i) licenses, or options to obtain licenses, to the Company’s antibody‑drug conjugate, or ADC, technology, (ii) rights to future technological improvements, (iii) research activities to be performed on behalf of the collaborative partner, (iv) delivery of cytotoxic agents and (v) the manufacture of preclinical or clinical materials for the collaborative partner. Payments to the Company under these agreements may include upfront fees, option fees, exercise fees, payments for research activities, payments for the manufacture of preclinical or clinical materials, payments based upon the achievement of certain milestones and royalties on product sales. The Company follows the provisions of the Financial Accounting Standards Board, or FASB, Accounting Standards Codification, or ASC, Topic 605‑25, “Revenue Recognition—Multiple‑Element Arrangements,” and ASC Topic 605‑28, “Revenue Recognition—Milestone Method,” in accounting for these agreements. In order to account for these agreements, the Company must identify the deliverables included within the agreement and evaluate which deliverables represent separate units of accounting based on whether certain criteria are met, including whether the delivered element has stand‑alone value to the collaborator. The consideration received is allocated among the separate units of accounting, and the applicable revenue recognition criteria are applied to each of the separate units.

At June 30, 2017, the Company had the following two material types of agreements with the parties identified below:

Development and commercialization licenses, which provide the party with the right to use the Company’s ADC technology and/or certain other intellectual property to develop compounds to a specified antigen target:

Amgen (two exclusive single-target licenses – one of which has been sublicensed to Oxford BioTherapeutics Ltd.)

Bayer (one exclusive single-target license)

Biotest (one exclusive single-target license)

CytomX (one exclusive single-target license)

Fusion Pharmaceuticals (one exclusive single-target license)

Lilly (three exclusive single-target licenses)

Novartis (five exclusive single-target licenses and one license to two related targets: one target on an exclusive basis and the second target on a non-exclusive basis)

Roche, through its Genentech unit (five exclusive single-target licenses)

Sanofi (five fully-paid, exclusive single-target licenses)

Takeda, through its wholly owned subsidiary, Millennium Pharmaceuticals, Inc. (one exclusive single-target license)

Debiopharm (one exclusive single-target license)

CytomX (one exclusive single-target license)

Research license/option agreement for a defined period of time to secure development and commercialization licenses to use the Company’s ADC technology to develop anticancer compounds to specified targets on established terms (referred to herein as right-to-test agreements):

Takeda, through its wholly owned subsidiary, Millennium Pharmaceuticals, Inc.

There are no performance, cancellation, termination or refund provisions in any of the arrangements that contain material financial consequences to the Company.

Development and Commercialization Licenses

The deliverables under a development and commercialization license agreement generally include the license to the Company’s ADC technology with respect to a specified antigen target, and may also include deliverables related to rights to future technological improvements, research activities to be performed on behalf of the collaborative partner and the manufacture of preclinical or clinical materials for the collaborative partner.

Generally, development and commercialization licenses contain non‑refundable terms for payments and, depending on the terms of the agreement, provide that the Company will (i) at the collaborator’s request, provide research services at negotiated prices which are generally consistent with what other third parties would charge, (ii) at the collaborator’s request, manufacture and provide to it preclinical and clinical materials or deliver cytotoxic agents at negotiated prices which are generally consistent with what other third parties would charge, (iii) earn payments upon the achievement of certain milestones and (iv) earn royalty payments, generally until the later of the last applicable patent expiration or 10 to 12 years after product launch. In the case of Kadcyla®, however, the minimum royalty term is 10 years and the maximum royalty term is 12 years on a country‑by‑country basis, regardless of patent protection. Royalty rates may vary over the royalty term depending on the Company’s intellectual property rights and/or the presence of comparable competing products. In the case of Sanofi, their licenses are fully-paid and no further milestones or royalties will be received. In the case of Debiopharm, no royalties will be received. The Company may provide technical assistance and share any technology improvements with its collaborators during the term of the collaboration agreements. The Company does not directly control when or whether any collaborator will request research or manufacturing services, achieve milestones or become liable for royalty payments. As a result, the Company cannot predict when or if it will recognize revenues in connection with any of the foregoing.

In determining the units of accounting, management evaluates whether the license has stand‑alone value from the undelivered elements to the collaborative partner based on the consideration of the relevant facts and circumstances for each arrangement. Factors considered in this determination include the research capabilities of the partner and the availability of ADC technology research expertise in the general marketplace. If the Company concludes that the license has stand‑alone value and therefore will be accounted for as a separate unit of accounting, the Company then determines the estimated selling prices of the license and all other units of accounting based on market conditions, similar arrangements entered into by third parties, and entity‑specific factors such as the terms of the Company’s previous collaborative agreements, recent preclinical and clinical testing results of therapeutic products that use the Company’s ADC technology, the Company’s pricing practices and pricing objectives, the likelihood that technological improvements will be made, and, if made, will be used by the Company’s collaborators and the nature of the research services to be performed on behalf of its collaborators and market rates for similar services.

Upfront payments on development and commercialization licenses may be recognized upon delivery of the license if facts and circumstances dictate that the license has stand‑alone value from the undelivered elements, which generally include rights to future technological improvements, research services, delivery of cytotoxic agents and the manufacture of preclinical and clinical materials.

The Company recognizes revenue related to research services that represent separate units of accounting as they are performed, as long as there is persuasive evidence of an arrangement, the fee is fixed or determinable, and collection of the related receivable is probable. The Company recognizes revenue related to the rights to future technological improvements over the estimated term of the applicable license.

The Company may also provide cytotoxic agents to its collaborators or produce preclinical and clinical materials at negotiated prices which are generally consistent with what other third parties would charge. The Company recognizes revenue on cytotoxic agents and on preclinical and clinical materials when the materials have passed all quality testing required for collaborator acceptance and title and risk of loss have transferred to the collaborator. Arrangement consideration allocated to the manufacture of preclinical and clinical materials in a multiple‑deliverable arrangement is below the Company’s full cost, and the Company’s full cost is not expected to ever be below its contract selling prices for its existing collaborations. During the six months ended June 30, 2017 and 2016, the difference between the Company’s full cost to manufacture preclinical and clinical materials on behalf of its collaborators as compared to total amounts received from collaborators for the manufacture of preclinical and clinical materials was $929,000 and $2.8 million, respectively. The majority of the Company’s costs to produce these preclinical and clinical materials are fixed and then allocated to each batch based on the number of batches produced during the period. Therefore, the Company’s costs to produce these materials are significantly affected by the number of batches produced during the period. The volume of preclinical and clinical materials the Company produces is directly related to the scale and scope of preclinical activities and the number of clinical trials the Company and its collaborators are preparing for or currently have underway, the speed of enrollment in those trials, the dosage schedule of each clinical trial and the time period such trials last. Accordingly, the volume of preclinical and clinical materials produced, and therefore the Company’s per‑batch costs to manufacture these preclinical and clinical materials, may vary significantly from period to period.

The Company may also produce research material for potential collaborators under material transfer agreements. Additionally, the Company performs research activities, including developing antibody specific conjugation processes, on behalf of its collaborators and potential collaborators during the early evaluation and preclinical testing stages of drug development. The Company records amounts received for research materials produced or services performed as a component of research and development support revenue. The Company also develops conjugation processes for materials for later stage testing and commercialization for certain collaborators. The Company is compensated at negotiated rates and may receive milestone payments for developing these processes which are recorded as a component of research and development support revenue.

The Company’s development and commercialization license agreements have milestone payments which for reporting purposes are aggregated into three categories: (i) development milestones, (ii) regulatory milestones, and (iii) sales milestones. Development milestones are typically payable when a product candidate initiates or advances into different clinical trial phases. Regulatory milestones are typically payable upon submission for marketing approval with the U.S. Food and Drug Administration, or FDA, or other countries’ regulatory authorities or on receipt of actual marketing approvals for the compound or for additional indications. Sales milestones are typically payable when annual sales reach certain levels.

At the inception of each agreement that includes milestone payments, the Company evaluates whether each milestone is substantive and at risk to both parties on the basis of the contingent nature of the milestone. This evaluation includes an assessment of whether (a) the consideration is commensurate with either (1) the entity’s performance to achieve the milestone, or (2) the enhancement of the value of the delivered item(s) as a result of a specific outcome resulting from the entity’s performance to achieve the milestone, (b) the consideration relates solely to past performance and (c) the consideration is reasonable relative to all of the deliverables and payment terms within the arrangement. The Company evaluates factors such as the scientific, regulatory, commercial and other risks that must be overcome to achieve the respective milestone, the level of effort and investment required to achieve the respective milestone and whether the milestone consideration is reasonable relative to all deliverables and payment terms in the arrangement in making this assessment.

Non‑refundable development and regulatory milestones that are expected to be achieved as a result of the Company’s efforts during the license period are considered substantive and are recognized as revenue upon the achievement of the milestone, assuming all other revenue recognition criteria are met. Milestones that are not considered substantive because we do not contribute significant effort to the achievement of such milestones are recognized as revenue upon achievement of the milestone, as long as there are no undelivered elements remaining and no continuing performance obligations, assuming all other revenue recognition criteria are met.

Under the Company’s development and commercialization license agreements, except for the Sanofi and Debiopharm licenses, the Company receives royalty payments based upon its licensees’ net sales of covered products. Generally, under these agreements the Company is to receive royalty reports and payments from its licensees approximately one quarter in arrears, that is, generally in the second or third month of the quarter after the licensee has sold the royalty bearing product or products. The Company recognizes royalty revenues when it can reliably estimate such amounts and collectability is reasonably assured. As such, the Company generally recognizes royalty revenues in the quarter reported to the Company by its licensees, or one quarter following the quarter in which sales by the Company’s licensees occurred.

Right‑to‑Test Agreements

The Company’s right‑to‑test agreements provide collaborators the right to (a) test the Company’s ADC technology for a defined period of time through a research, or right‑to‑test, license, (b) take options, for a defined period of time, to specified targets and (c) upon exercise of those options, secure or “take” licenses to develop and commercialize products for the specified targets on established terms. Under these agreements, fees may be due to the Company (i) at the inception of the arrangement (referred to as “upfront” fees or payments), (ii) upon taking an option with respect to a specific target (referred to as option fees or payments earned, if any, when the option is “taken”), (iii) upon the exercise of a previously taken option to acquire a development and commercialization license(s) (referred to as exercise fees or payments earned, if any, when the development and commercialization license is “taken”), or (iv) some combination of all of these fees.

The accounting for right to test agreements is dependent on the nature of the options granted to the collaborative partner. Options are considered substantive if, at the inception of a right to test agreement, the Company is at risk as to whether the collaborative partner will choose to exercise the options to secure development and commercialization licenses. Factors that are considered in evaluating whether options are substantive include the overall objective of the arrangement, the benefit the collaborator might obtain from the agreement without exercising the options, the cost to exercise the options relative to the total upfront consideration, and the additional financial commitments or economic penalties imposed on the collaborator as a result of exercising the options. None of the Company’s right to test agreements entered into subsequent to the adoption of Accounting Standards Update, or ASU, No. 2009 13, “Revenue Arrangements with Multiple Deliverables” on July 1, 2010 has been determined to contain substantive options. For right to test agreements where the options to secure development and commercialization licenses to the Company’s ADC technology are not considered substantive, the Company considers the development and commercialization licenses to be a deliverable at the inception of the agreement and applies the multiple element revenue recognition criteria to determine the appropriate revenue recognition. Subsequent to the adoption of ASU No. 2009-13, the Company determined that its research licenses lack stand-alone value and are considered for aggregation with the other elements of the arrangement and accounted for as one unit of accounting.

The Company does not control when or if any collaborator will exercise its options for development and commercialization licenses. As a result, the Company cannot predict when or if it will recognize revenues in connection with any of the foregoing.

Financial Instruments and Concentration of Credit Risk

Cash and cash equivalents are primarily maintained with three financial institutions in the U.S. Deposits with banks may exceed the amount of insurance provided on such deposits. Generally, these deposits may be redeemed upon demand and, therefore, bear minimal risk. The Company’s cash equivalents consist of money market funds with underlying investments primarily being U.S. Government issued securities and high quality, short term commercial paper. Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash, cash equivalents and marketable securities. The Company held no marketable securities as of June 30, 2017 and December 31, 2016. The Company’s investment policy, approved by the Board of Directors, limits the amount it may invest in any one type of investment, thereby reducing credit risk concentrations.

Cash and Cash Equivalents

All highly liquid financial instruments with maturities of three months or less when purchased are considered cash equivalents. As of June 30, 2017 and December 31, 2016, the Company held $150.3 million and $160.0 million, respectively, in cash and money market funds consisting principally of U.S. Government-issued securities and high quality, short-term commercial paper which were classified as cash and cash equivalents.

Non-cash Investing Activities

The Company had approximately $14,000 and $356,000 of accrued capital expenditures as of June 30, 2017 and December 31, 2016, respectively, which have been treated as a non-cash investing activity and, accordingly, are not reflected in the consolidated statement of cash flows.

Fair Value of Financial Instruments

Fair value is defined under ASC Topic 820, “Fair Value Measurements and Disclosures,” as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The standard describes a fair value hierarchy to measure fair value which is based on three levels of inputs, of which the first two are considered observable and the last unobservable, as follows:

Level 1 - Quoted prices in active markets for identical assets or liabilities.

Level 2 - Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3 – Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

As of June 30, 2017, the Company held certain assets that are required to be measured at fair value on a recurring basis. The following table represents the fair value hierarchy for the Company’s financial assets measured at fair value on a recurring basis as of June 30, 2017 (in thousands):

Fair Value Measurements at June 30, 2017 Using

Quoted Prices in

Significant

Active Markets for

Significant Other

Unobservable

Identical Assets

Observable Inputs

Inputs

Total

(Level 1)

(Level 2)

(Level 3)

Cash equivalents

131,469

—

As of December 31, 2016, the Company held certain assets that are required to be measured at fair value on a recurring basis. The following table represents the fair value hierarchy for the Company’s financial assets measured at fair value on a recurring basis as of December 31, 2016 (in thousands):

Fair Value Measurements at December 31, 2016 Using

Quoted Prices in

Significant

Active Markets for

Significant Other

Unobservable

Identical Assets

Observable Inputs

Inputs

Total

(Level 1)

(Level 2)

(Level 3)

Cash equivalents

144,176

—

The fair value of the Company’s cash equivalents is based on quoted prices from active markets.

The carrying amounts reflected in the consolidated balance sheets for accounts receivable, unbilled revenue, prepaid and other current assets, accounts payable, accrued compensation, and other accrued liabilities approximate fair value due to their short‑term nature. The gross carrying amount and estimated fair value of the convertible 4.5% senior notes was $100.0 million and $181.5 million, respectively, as of June 30, 2017 compared to $100.0 million and $79.0 million, respectively, as of December 31, 2016. The increase in estimated fair value as of June 30, 2017 compared to December 31, 2016 is due primarily to an increase in the Company’s stock price. The fair value of the Convertible Notes is influenced by interest rates, the Company’s stock price and stock price volatility and is determined by prices for the Convertible Notes observed in a market which is a Level 2 input for fair value purposes.

Unbilled Revenue

The majority of the Company’s unbilled revenue at June 30, 2017 represents research funding earned prior to that date based on actual resources utilized under the Company’s agreements with various collaborators. In addition to that type of unbilled revenue, also included in unbilled revenue at December 31, 2016 was a $5 million partner milestone achieved in December 2016 which was subsequently invoiced and paid in the first quarter of 2017.

Inventory

Inventory costs relate to clinical trial materials being manufactured for sale to the Company’s collaborators. Inventory is stated at the lower of cost or net realizable value as determined on a first-in, first-out (FIFO) basis.

Inventory at June 30, 2017 and December 31, 2016 is summarized below (in thousands):


	June 30,		December 31,
	2017		2016
Raw materials	$	124	$	357
Work in process		3,358		1,835
Total	$	3,482	$	2,192

Raw materials inventory consists entirely of proprietary cell‑killing agents the Company developed as part of its ADC technology. All raw materials inventory is currently procured from two suppliers. The Company considers more than a twelve month supply of raw materials that is not supported by firm, fixed orders and/or projections from its collaborators to be excess and establishes a reserve to reduce to zero the value of any such excess raw material inventory with a corresponding charge to research and development expense. In accordance with this policy, the Company recorded $403,000 of expense related to excess inventory in the six months ended June 30, 2017 as a result of inventory purchased in the current period in order to manufacture drug product to supply the Company’s mirvetuximab soravtansine studies. There were no expenses recorded for excess inventory during the three month period ended June 30, 2017 and the three and six-month periods ended June 30, 2016.

Work in process inventory consists of conjugate manufactured for sale to the Company’s collaborators to be used in preclinical and clinical studies. All conjugate is made to order at the request of the collaborators and subject to the terms and conditions of respective supply agreements. Based on historical reprocessing or reimbursement required for conjugate that did not meet specification and status of current conjugate on hand or conjugate shipped to collaborators but not yet released per the terms of the respective supply agreements, no reserve for work in process inventory was determined to be required at June 30, 2017. As discussed above, the Company’s costs to manufacture conjugate on behalf of its partners are greater than the supply prices charged to partners, and therefore costs are capitalized into inventory at the supply prices which represents net realizable value.

Computation of Net Loss per Common Share

Basic and diluted net loss per share is calculated based upon the weighted average number of common shares outstanding during the period. During periods of income, participating securities are allocated a proportional share of income determined by dividing total weighted average participating securities by the sum of the total weighted average common shares and participating securities (the “two-class method”). Shares of the Company’s restricted stock participate in any dividends declared by the Company and are therefore considered to be participating securities. Participating securities have the effect of diluting both basic and diluted earnings per share during periods of income. During periods of loss, no loss is allocated to participating securities since they have no contractual obligation to share in the losses of the Company. Diluted (loss) income per share is computed after giving consideration to the dilutive effect of stock options and restricted stock that are outstanding during the period, except where such non-participating securities would be anti-dilutive.

The Company’s common stock equivalents, as calculated in accordance with the treasury‑stock method for the options and the if-converted method for the convertible notes, are shown in the following table (in thousands):


	Three Months Ended		Six Months Ended
	June 30,		June 30,
	2017	2016	2017	2016
Options outstanding to purchase common stock and unvested restricted stock	15,588	11,919	15,588	11,919
Common stock equivalents under treasury stock method for options	1,224	232	463	297
Shares issuable upon conversion of convertible notes	23,878	23,878	23,878	23,878
Common stock equivalents under if-converted method for convertible notes	23,878	2,886	23,878	1,443

The Company’s common stock equivalents have not been included in the net loss per share calculation because their effect is anti‑dilutive due to the Company’s net loss position.

Stock-Based Compensation

As of June 30, 2017, the Company is authorized to grant future awards under one employee share‑based compensation plan, which is the ImmunoGen, Inc. 2016 Employee, Director and Consultant Equity Incentive Plan, or the 2016 Plan. At the annual meeting of shareholders on December 9, 2016, the 2016 Plan was approved and provides for the issuance of Stock Grants, the grant of Options and the grant of Stock‑Based Awards for up to 5,500,000 shares of the Company’s common stock, as well as up to 14,250,000 shares of common stock which represent awards granted under the previous stock option plan, the ImmunoGen, Inc. 2006 Employee, Director and Consultant Equity Incentive Plan, or the 2006 Plan, that forfeit, expire, or cancel without delivery of shares of common stock or which resulted in the forfeiture of shares of common stock back to the Company subsequent to December 9, 2016. At the annual meeting of shareholders on June 13, 2017, the 2016 Plan was amended to increase the number of shares authorized for issuance thereunder by 1,000,000. Option awards are granted with an exercise price equal to the market price of the Company’s stock at the date of grant. Options vest at various periods of up to four years and may be exercised within ten years of the date of grant.

The stock-based awards are accounted for under ASC Topic 718, “Compensation—Stock Compensation.” Pursuant to Topic 718, the estimated grant date fair value of awards is charged to the statement of operations and comprehensive loss over the requisite service period, which is the vesting period. Such amounts have been reduced by an estimate of forfeitures of all unvested awards. The fair value of each stock option is estimated on the date of grant using the Black-Scholes option-pricing model with the assumptions noted in the following table. As the Company has not paid dividends since inception, nor does it expect to pay any dividends for the foreseeable future, the expected dividend yield assumption is zero. Expected volatility is based exclusively on historical volatility data of the Company’s stock. The expected term of stock options granted is based exclusively on historical data and represents the period of time that stock options granted are expected to be outstanding. The expected term is calculated for and applied to one group of stock options as the Company does not expect substantially different exercise or post-vesting termination behavior among its option recipients. The risk-free rate of the stock options is based on the U.S. Treasury rate in effect at the time of grant for the expected term of the stock options.



	Three Months Ended June 30,				Six Months Ended June 30,
	2017		2016		2017		2016
Dividend	None		None		None		None
Volatility	68.17	%	64.13	%	67.10	%	64.06	%
Risk-free interest rate	1.90	%	1.40	%	2.01	%	1.46	%
Expected life (years)	6.0		6.3		6.0		6.3

Using the Black-Scholes option-pricing model, the weighted average grant date fair values of options granted during the three months ended June 30, 2017 and 2016 were $2.86 and $3.44 per share, respectively, and $1.75 and $4.10 per share for options granted during the six months ended June 30, 2017 and 2016, respectively.

A summary of option activity under the 2006 and 2016 Plans as of June 30, 2017, and changes during the six month period then ended is presented below (in thousands, except weighted-average data):


		Weighted-
	Number	Average
	of Stock	Exercise
	Options	Price
Outstanding at December 31, 2016	13,679	$	10.70
Granted	1,428	$	2.84
Exercised	(10)		3.30
Forfeited/Canceled	(1,916)	$	10.47
Outstanding at June 30, 2017	13,181	$	9.89

During the six months ended June 30, 2017, holders of options issued under the Company’s equity plans exercised their rights to acquire an aggregate of approximately 10,000 shares of common stock at price of $3.30 per share. The total proceeds to the Company from these option exercises were approximately $32,000.

In August 2016, February 2017 and June 2017, the Company granted 117,800, 529,830 and 239,000 shares of restricted common stock with grant date fair values of $3.15, $2.47 and $4.71, respectively, to certain officers of the Company. These restrictions will lapse in three equal installments upon the achievement of specified performance goals within the next five years. The Company determined it is not currently probable that these performance goals will be achieved, and therefore, no expense has been recorded to date.

A summary of restricted stock activity under the 2006 and 2016 Plans (inclusive of the performance awards noted above) as of June 30, 2017 and changes during the six month period ended June 30, 2017 is presented below (in thousands except weighted-average data):



		Number of
		Restricted
		Stock Shares
Unvested at December 31, 2016		199
Awarded		2,253
Vested		(25)
Forfeited		(20)
Unvested at June 30, 2017		2,407

Stock compensation expense related to stock options and restricted stock awards granted under the 2016 and 2006 Plans was $3.1 million and $5.7 million during the three and six months ended June 30, 2017, respectively, compared to stock compensation expense of $4.5 million and $11.6 million for the three and six months ended June 30, 2016, respectively. During the six months ended June 30, 2016, the Company recorded $3.1 million of stock compensation cost related to the modification of certain outstanding common stock options with the former Chief Executive Officer’s succession plan. The decrease in expense is also attributable to lower fair values associated with awards expensed in the current period, level of forfeitures experienced since the prior year due to the restructuring disclosed in Note G and greater forfeitures recorded in the current period substantially resulting from the departure of certain senior-level employees. As of June 30, 2017, the estimated fair value of unvested employee awards was $15.0 million, net of estimated forfeitures. The weighted-average remaining vesting period for these awards is approximately two years. Also included in stock compensation expense for the three and six months ended June 30, 2017 and 2016 is expense recorded for directors’ deferred share units, the details of which are discussed in Note F.

Segment Information

During the six months ended June 30, 2017, the Company continued to operate in one operating segment which is the business of discovery of monoclonal antibody-based anticancer therapeutics.

The percentages of revenues recognized from significant customers of the Company in the six months ended June 30, 2017 and 2016 are included in the following table:


	Three Months Ended				Six Months Ended
	June 30,				June 30,
Collaborative Partner:	2017		2016		2017		2016
Bayer	—	%	—	%	—	%	37	%
CytomX	3	%	10	%	22	%	5	%
Roche	17	%	80	%	21	%	49	%
Sanofi	77	%	—	%	53	%	—	%

There were no other customers of the Company with significant revenues in the six months ended June 30, 2017 and 2016.

Recent Accounting Pronouncements

In May 2014, the FASB issued ASU 2014‑9, Revenue from Contracts with Customers (Topic 606) (“ASU 2014-09”), to clarify the principles for recognizing revenue. This update provides a comprehensive new revenue recognition model that requires revenue to be recognized in a manner to depict the transfer of goods or services to a customer at an amount that reflects the consideration expected to be received in exchange for those goods or services. In August 2015, the FASB issued ASU No. 2015-14, Revenue from Contracts with Customers (Topic 606): Deferral of the Effective Date, which delayed the effective date of the new standard from January 1, 2017 to January 1, 2018. The FASB also agreed to allow entities to choose to adopt the standard as of the original effective date. In March 2016, the FASB issued ASU No. 2016-08, Revenue from Contracts with Customers (Topic 606): Principal versus Agent Considerations, which clarifies the implementation guidance on principal versus agent considerations. In April 2016, the FASB issued ASU No. 2016-10, Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing, which clarifies certain aspects of identifying performance obligations and licensing implementation guidance. In May 2016, the FASB issued ASU No. 2016-12, Revenue from Contracts with Customers (Topic 606): Narrow-Scope Improvements and Practical Expedients related to disclosures of remaining performance obligations, as well as other amendments to guidance on collectability, non-cash consideration and the presentation of sales and other similar taxes collected from customers. These standards have the same effective date and transition date of January 1, 2018. The new revenue standard allows for either full retrospective or modified retrospective application. The Company anticipates using the modified retrospective approach to implement this standard. The Company is in the process of analyzing its existing revenue agreements to evaluate the impact of adoption. The Company has less than twenty contracts that have remaining performance obligations that will need to be evaluated under the provisions of the new standard as of January 1, 2018. In performing this assessment, the Company noted that we will be required to recognize royalty income in the same period as the related sales occur on Kadcyla rather than one quarter in arrears, which is the point in which the amount is fixed and determinable. This will require the Company to make an estimate of the royalties as the information is not provided to the Company until 90 days after the end of the quarter. Additionally, some partner milestones, depending on the probability of occurring, may be recognized sooner and at different values than they currently would be under the current accounting standards. The Company is in the process of estimating the impact of adopting the new standard on its consolidated financial statements, however, the Company expects to record a material adjustment upon adoption, which will be recorded as a cumulative effect of initially applying the standard to opening accumulated deficit as of January 1, 2018. The Company will continue to provide disclosures under the legacy accounting for the year ended December 31, 2018.

In July 2015, the FASB issued ASU 2015-11, Simplifying the Measurement of Inventory (Topic 330). To simplify the principles for subsequent measurement of inventory, this new standard requires inventory measured using any method other than LIFO or the retail method shall be measured at the lower of cost and net realizable value, rather than lower of cost or market. This guidance is effective for annual reporting beginning after December 15, 2016, including interim periods within the year of adoption, and calls for prospective application, with early application permitted. Accordingly, the standard was adopted by the Company on January 1, 2017. The adoption of this guidance did not have a material impact on the Company’s consolidated financial statements.

In January 2016, the FASB issued ASU 2016-1, Recognition and Measurement of Financial Assets and Financial Liabilities (Topic 825). The amendments in this Update supersede the guidance to classify equity securities with readily determinable fair values into different categories (that is, trading or available-for-sale) and require equity securities (including other ownership interests, such as partnerships, unincorporated joint ventures, and limited liability companies) to be measured at fair value with changes in the fair value recognized through net income. The amendments allow equity investments that do not have readily determinable fair values to be remeasured at fair value either upon the occurrence of an observable price change or upon identification of an impairment. The amendments also require enhanced disclosures about those investments. The amendments improve financial reporting by providing relevant information about an entity’s equity investments and reducing the number of items that are recognized in other comprehensive income. This guidance is effective for annual reporting beginning after December 15, 2017, including interim periods within the year of adoption, and calls for prospective application, with early application permitted. Accordingly, the standard is effective for the Company on January 1, 2018. The adoption of this guidance is not expected to have a material impact on the Company’s consolidated financial statements.

In February 2016, the FASB issued ASU 2016-2, Leases (Topic 842) that primarily requires lessees to recognize most leases on their balance sheets but record expenses on their income statements in a manner similar to current accounting. For lessors, the guidance modifies the classification criteria and the accounting for sales-type and direct financing leases. The guidance is effective for fiscal years beginning after December 15, 2018, including interim periods within those fiscal years, and calls for retrospective application, with early adoption permitted. Accordingly, the standard is effective for the Company on January 1, 2019. The Company is currently evaluating the impact of this guidance on our financial statements and the timing of adoption.

In March 2016, the FASB issued ASU 2016-9, Improvements to Employee Share-Based Payment Accounting (Topic 718) that changes the accounting for certain aspects of share-based payments to employees. The guidance requires the recognition of the income tax effects of awards in the income statement when the awards vest or are settled, thus eliminating additional paid in capital pools. The guidance also allows for the employer to repurchase more of an employee’s shares for tax withholding purposes without triggering liability accounting. In addition, the guidance allows for a policy election to account for forfeitures as they occur rather than on an estimated basis. The guidance is effective for annual periods beginning after December 15, 2016, and interim periods within those annual periods with early adoption permitted. Accordingly, the standard was adopted by the Company on January 1, 2017. As a result of the adoption of this guidance, the net operating loss deferred tax assets for federal and state purposes increased by $9.2 million and $1.2 million, respectively, and will be offset by corresponding increases in the valuation allowance. The adoption of the guidance has no impact on the Company’s consolidated financial statements. The Company elected not to adopt the provision that would allow actual forfeitures to be recognized in lieu of maintaining a forfeitures reserve. As such, the Company will continue to estimate forfeitures.

Agreements	6 Months Ended
Agreements	Jun. 30, 2017
Agreements
Agreements	C. Agreements Significant Collaborative Agreements Roche In 2000, the Company granted Genentech, now a unit of Roche, an exclusive license to use the Company’s maytansinoid ADC technology with antibodies, such as trastuzumab, or other proteins that target HER2. Under the terms of this agreement, Roche has exclusive worldwide rights to develop and commercialize maytansinoid ADC compounds targeting HER2. In 2013, the HER2‑targeting ADC compound, Kadcyla, was approved for marketing in the U.S., Japan and the European Union, or EU. Roche has also received marketing approval in various other countries around the world. Roche is responsible for the manufacturing, product development and marketing of any products resulting from the agreement. The Company received a $2 million non‑refundable upfront payment from Roche upon execution of the agreement. The Company is also entitled to receive up to a total of $44 million in milestone payments, plus royalties on the commercial sales of Kadcyla or any other resulting products. Total milestones are categorized as follows: development milestones—$13.5 million; and regulatory milestones—$30.5 million. Through June 30, 2017, the Company has received and recognized $13.5 million and $20.5 million in development and regulatory milestone payments, respectively, related to Kadcyla. The next potential milestone the Company will be entitled to receive will be a $5 million regulatory milestone for marketing approval of Kadcyla for a first extended indication as defined in the agreement. Based on an evaluation of the effort contributed towards the achievement of this future milestone, the Company determined this milestone is not substantive. The Company receives royalty reports and payments related to sales of Kadcyla from Roche one quarter in arrears. In accordance with the Company’s revenue recognition policy, $14.1 million of non-cash royalties on net sales of Kadcyla for the six‑month period ended March 31, 2017 were recorded and included in non-cash royalty revenue for the six-month period ended June 30, 2017 and $13.3 million of non-cash royalties on net sales of Kadcyla for the six‑month period ended March 31, 2016 is included in non-cash royalty revenue for the six-month period ended June 30, 2016. Kadcyla sales occurring after January 1, 2015 are covered by a royalty purchase agreement whereby the associated cash is remitted to Immunity Royalty Holdings, L.P, or IRH, as discussed further in Note E. Sanofi On May 30, 2017, the Company and an affiliate of Sanofi amended the license agreements covering all compounds in development by Sanofi using the Company’s technology. Under the terms of the amended 2003 collaboration and license agreement, the Company granted Sanofi a fully-paid, exclusive license to develop, manufacture, and commercialize four experimental compounds in development. The Company and Sanofi also amended a separate 2013 exclusive license to grant Sanofi a fully-paid, exclusive license to develop, manufacture and commercialize another experimental compound being studied for the treatment of solid tumors. As consideration for these amendments, the Company received a $30 million payment and agreed to forego a limited co-promotion option in the U.S. with respect to the compounds covered by the 2003 agreement, as well as future milestones or royalties under both license agreements. In accordance with ACS-605-25 (as amended by ASU No. 2009-13), the Company determined that there were no remaining deliverables upon execution of the amendments, and accordingly, the $30 million has been recognized as revenue and is included in license and milestone fee revenue for the three and six months ended June 30, 2017. Bayer In 2008, the Company granted Bayer an exclusive development and commercialization license to the Company’s maytansinoid ADC technology for use with antibodies or other proteins that target mesothelin. Bayer HealthCare is responsible for the research, development, manufacturing, and marketing of any products resulting from the license. The Company received a $4 million upfront payment upon execution of the agreement which was recognized as revenue ratably over the Company’s estimated period of substantial involvement which concluded in September 2012. For each compound developed and marketed by Bayer under this collaboration the Company is entitled to receive a total of $170.5 million in milestone payments, plus tiered royalties between 4 - 7% on the commercial sales of any resulting products. The total milestones are categorized as follows: development milestones—$16 million; regulatory milestones—$44.5 million; and sales milestones—$110 million. Through June 30, 2017, the Company has received and recognized an aggregate of $13 million in milestone payments under this agreement. In January 2016, Bayer initiated a Phase 2 clinical study designed to support registration of its ADC product candidate, anetumab ravtansine, triggering a $10 million development milestone payment to the Company which is included in license and milestone fee revenue for the six months ended June 30, 2016. The next potential milestone the Company will be entitled to receive will be a development milestone for commencement of a pivotal clinical trial for a second indication for anetumab ravtansine, which will result in a $2 million payment being due. At the time of execution of this agreement, there was significant uncertainty as to whether these milestones would be achieved. In consideration of this, as well as the Company’s past involvement in the research and supply of cytotoxic agent for this product candidate, these milestones were deemed substantive. CytomX In January 2014, we entered into a reciprocal right‑to‑test agreement with CytomX. The agreement provides CytomX with the right to test our payload agents and linkers with CytomX antibodies that utilize their proprietary antibody-masking technology, termed ProbodiesTM for a specified number of targets and to subsequently take an exclusive, worldwide license to use our technology to develop and commercialize Probody-drug conjugates directed to the specified targets on terms agreed upon at the inception of the right‑to‑test agreement. We received no upfront cash payment in connection with the execution of the right‑to‑test agreement. Instead, we received reciprocal rights to test our payload agents and linkers with ImmunoGen antibodies masked using CytomX technology to create Probody-drug conjugates directed to a specified number of targets and to subsequently take exclusive, worldwide licenses to develop and commercialize such conjugates directed to the specified targets on terms agreed upon at the inception of the right‑to‑test agreement. The terms of the right‑to‑test agreement require us and CytomX to each take its respective development and commercialization licenses by the end of the term of the research license. In addition, both we and CytomX are required to perform specific research activities under the right‑to‑test agreement on behalf of the other party for no monetary consideration. In February 2016, CytomX took its development and commercialization license for a specified target. An amendment of the agreement executed simultaneously with that license granted CytomX the right, for a specified period of time, to substitute the specified target with another as yet unspecified target. Accordingly, the revenue associated with this license was deferred until the expiration of that substitution right in January 2017, whereupon we recognized $12.7 million of the $13 million of arrangement consideration allocated to the development and commercialization license, which is included in license and milestone fee revenue for the six months ended June 30, 2017. With respect to the development and commercialization license taken by CytomX, the Company is entitled to receive up to a total of $160 million in milestone payments plus royalties on the commercial sales of any resulting product. The total milestones are categorized as follows: development milestones—$10 million; regulatory milestones—$50 million; and sales milestones—$100 million. In June 2017, CytomX enrolled its first patient in a Phase 1 clinical trial for its product candidate, CX-2009, triggering a $1 million development milestone payment which is included in license and milestone fee revenue for the three and six months ended June 30, 2017. The next payment the Company could receive would be a $3 million development milestone payment with commencement of a Phase 2 clinical trial. At the time of execution of the right-to-test agreement, there was significant uncertainty as to whether the milestone related to the Phase 2 clinical trial would be achieved. In consideration of this, as well as the Company's expected involvement in the research and manufacturing of any product candidate, this milestone was deemed substantive. CytomX is responsible for the manufacturing, product development and marketing of any product resulting from the development and commercialization license taken by CytomX under this collaboration. Debiopharm On May 24, 2017, Debiopharm International SA (Debiopharm) acquired the Company’s IMGN529 program, a clinical-stage anti-CD37 ADC for the treatment of patients with B-cell malignancies, such as non-Hodgkin lymphomas (NHL). Under the terms of the Exclusive License and Asset Purchase agreement, the Company received a $25 million upfront payment for specified assets related to IMGN529 and a paid-up license to the Company’s ADC technology, and is entitled to a $5 million milestone payment to be paid after substantial completion of the transfer of ImmunoGen technologies related to the program (technology transfer), which the parties expect to achieve by the end of 2017. In addition, ImmunoGen is eligible for a second success-based milestone payment of $25 million upon IMGN529 entering a Phase 3 clinical trial. The milestone payment will be significantly reduced if a Phase 3 trial using the Company’s technology but not the IMGN529 antibody commences prior to IMGN529 entering a Phase 3 trial. The Company does not believe this scenario is likely to occur. In accordance with ACS 605 25 (as amended by ASU No. 2009 13), the Company identified all of the deliverables at the inception of the agreement. The significant deliverables were determined to be the license, the tech transfer and certain related physical materials. Since the technology being used is no longer the focus of the Company’s research efforts, and IMGN529 is already in clinical trials which significantly lessens the probability that it would be changed, the value of the rights to future technological improvements which was granted in the agreement was considered immaterial. The Company has determined that the license, together with the technology transfer, represent one unit of accounting as the license does not have standalone value from the Company’s responsibility tro complete the technology transfer because 1) there are no other vendors selling similar licenses on a standalone basis, 2) the transfer can only be performed by the Company and 3) Debiopharm is unable to use the license for its intended purpose without the technology transfer. The related physical materials have stand-alone value as these items could be produced by other vendors. The estimated selling price for the license/technology transfer is the Company’s best estimate of selling price and was determined based on market conditions, similar arrangements entered into by third parties, including the Company’s understanding of pricing terms offered by its competitors for single-target licenses that utilize the Company’s ADC technology, the clinical stage of the product being sold, and entity-specific factors such as the pricing terms of the Company’s previous single target licenses, recent preclinical and clinical testing results of therapeutic products that use the Company’s ADC technology, and the Company’s pricing practices and pricing objectives. The estimated selling price of the related materials was based on third party evidence given the nature of the items and the market rates for similar items. The total arrangement consideration of $30 million (which comprises the $25 million upfront payment and the transfer fee of $5 million) was allocated to the units of accounting based on the relative selling price method as follows: $29.7 million to the license/technology transfer and $300,000 to the physical materials. The Company will record $29.7 million of revenue as outlined above when the technology transfer work is substantially complete, which is the final item delivered in the unit of accounting and the value of the physical materials will be recorded as revenue when delivered. As of June 30, 2017, $25 million was recorded in short-term deferred revenue, which represents the full amount of the upfront payment received. For additional information related to these agreements, as well as the Company’s other significant collaborative agreements, please read Note C, Agreements, to the consolidated financial statements included within the Company’s 2016 Transition Report on Form 10-K

Convertible 4.5% Senior Notes	6 Months Ended
Convertible 4.5% Senior Notes	Jun. 30, 2017
Convertible 4.5% Senior Notes
Convertible 4.5% Senior Notes	D. Convertible 4.5% Senior Notes In June 2016, the Company issued Convertible 4.5% Senior Notes with an aggregate principal amount of $100 million. The Company received net proceeds of approximately $96.6 million from the sale of the Convertible Notes, after deducting fees and expenses of approximately $3.4 million. The Convertible Notes are governed by the terms of an indenture between the Company, as issuer, and Wilmington Trust, National Association, as the trustee. The Convertible Notes are senior unsecured obligations and bear interest at a rate of 4.5% per year, payable semi-annually in arrears on January 1 and July 1 of each year, commencing on January 1, 2017. The Company recorded approximately $2.3 million and $138,000 of interest expense in the six months ended June 30, 2017 and 2016, respectively. The Convertible Notes will mature on July 1, 2021, unless earlier repurchased or converted. Holders may convert their notes at their option at any time prior to the close of business on the business day immediately preceding the stated maturity date. Upon conversion, the Company will deliver for each $1,000 principal amount of converted notes a number of shares equally to the conversion rate, which will initially be 238.7775 shares of common stock, equivalent to an initial conversion price of approximately $4.19. The conversion rate will be subject to adjustment in some circumstances, but will not be adjusted for any accrued and unpaid interest. In addition, if a “make-whole fundamental change” (as defined in the offering memorandum) occurs prior to the stated maturity date, the Company will increase the conversion rate for a holder who elects to convert its notes in connection with such make-whole fundamental change in certain circumstances. If the Company undergoes a fundamental change, subject to certain conditions, holders may require the Company to repurchase for cash all or part of their notes at a purchase price equal to 100% of the principal amount of the notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change purchase date. In addition, upon an event of default, the holders may require the Company to repurchase for cash all of their notes at a purchase price equal to 100% of the principal amount, plus accrued and unpaid interest. Upon bankruptcy, this becomes an automatic repurchase obligation. Also, if the Company fails to comply with certain reporting requirements as described in the indenture it will constitute an event of default, however the Company may elect to pay additional interest at an annual rate equal to 0.5% of the principal amount for the 90 days following such event as a remedy for the default. Subsequent to the 90 days, if still in default, the principal amount of the notes and accrued interest may become immediately due and payable. If a “restricted event” occurs as described in the indenture that causes the notes not to become freely tradable by holders other than our affiliates after the first anniversary of the original issuance date of the notes, the Company would also become obligated to pay additional interest at an annual rate equal to 0.5% of the principal amount. The combined additional interest rate under these two circumstances, however, cannot exceed 0.5%. The Company analyzed the terms of the Convertible Notes and determined that under current accounting guidance the notes would be entirely accounted for as debt and none of the terms of the notes require separate accounting. As part of the issuance of the Convertible Notes, the Company incurred $3.4 million of transaction costs, which are netted against the Convertible Notes in the accompanying consolidated balance sheet and are being amortized to interest expense ratably over the term of the Convertible Notes.

Liability Related to Sale of Future Royalties

6 Months Ended

Jun. 30, 2017

E. Liability Related to Sale of Future Royalties

In April 2015, Immunity Royalty Holdings, L.P. (IRH) purchased the right to receive 100% of the royalty payments on commercial sales of Kadcyla subsequent to December 31, 2014, arising under the Company’s development and commercialization license with Genentech (a unit of Roche), until IRH has received aggregate royalties equal to $235 million or $260 million, depending on when the aggregate royalties received by IRH reach a specified milestone. Once the applicable threshold is met, if ever, the Company will thereafter receive 85% and IRH will receive 15% of the Kadcyla royalties for the remaining royalty term. At consummation of the transaction in April 2015, the Company received cash proceeds of $200 million. As part of this sale, the Company incurred $5.9 million of transaction costs, which are presented net of the liability in the accompanying consolidated balance sheet and will be amortized to interest expense over the estimated life of the royalty purchase agreement. Although the Company sold its rights to receive royalties from the sales of Kadcyla, as a result of its ongoing involvement in the cash flows related to these royalties, the Company will continue to account for these royalties as revenue and recorded the $200 million in proceeds from this transaction as a liability related to sale of future royalties (Royalty Obligation) that will be amortized using the interest method over the estimated life of the royalty purchase agreement.

The following table shows the activity within the liability account during the six-month period ended June 30, 2017 (in thousands):


	Period from
	December 31, 2016 to
	June 30, 2017
Liability related to sale of future royalties, net — beginning balance	$	184,328
Non-cash Kadcyla royalty revenue		(14,052)
Non-cash interest expense recognized		6,741
Liability related to sale of future royalties, net — ending balance	$	177,017

As royalties are remitted to IRH, the balance of the Royalty Obligation will be effectively repaid over the life of the agreement. In order to determine the amortization of the Royalty Obligation, the Company is required to estimate the total amount of future royalty payments to be received and remitted to IRH as noted above over the life of the agreement. The sum of these amounts less the $200 million proceeds the Company received will be recorded as interest expense over the life of the Royalty Obligation. Since inception, the Company’s estimate of this total interest expense resulted in an effective annual interest rate of approximately 7.7%. The Company periodically assesses the estimated royalty payments to IRH and to the extent such payments are greater or less than its initial estimates, or the timing of such payments is materially different than its original estimates, the Company will prospectively adjust the amortization of the Royalty Obligation. There are a number of factors that could materially affect the amount and timing of royalty payments from Genentech, most of which are not within the Company’s control. Such factors include, but are not limited to, changing standards of care, the introduction of competing products, manufacturing or other delays, biosimilar competition, patent protection, adverse events that result in governmental health authority imposed restrictions on the use of the drug products, significant changes in foreign exchange rates as the royalties remitted to IRH are made in U.S. dollars (USD) while significant portions of the underlying sales of Kadcyla are made in currencies other than USD, and other events or circumstances that could result in reduced royalty payments from Kadcyla, all of which would result in a reduction of non-cash royalty revenues and the non-cash interest expense over the life of the Royalty Obligation. Conversely, if sales of Kadcyla are more than expected, the non-cash royalty revenues and the non-cash interest expense recorded by the Company would be greater over the term of the Royalty Obligation.

In addition, the royalty purchase agreement grants IRH the right to receive certain reports and other information relating to the royalties and contains other representations and warranties, covenants and indemnification obligations that are customary for a transaction of this nature.

Capital Stock	6 Months Ended
Capital Stock	Jun. 30, 2017
Capital Stock
Capital Stock	F. Capital Stock 2001 Non-Employee Director Stock Plan During the three and six months ended June 30, 2017, the Company recorded approximately $21,000 and $32,000 in expense related to stock units outstanding under the Company’s 2001 Non-Employee Director Stock Plan, or the 2001 Plan, compared to $(35,000) and $(67,000) in expense reduction recorded during the three and six months ended June 30, 2016. The value of the stock units are classified as a liability and adjusted to market value at each reporting period as the redemption amount of stock units for this plan will be paid in cash. No stock units have been issued under the 2001 Plan subsequent to June 30, 2004. Compensation Policy for Non-Employee Directors On December 9, 2016 the Board amended the Compensation Policy for Non-Employee Directors to create a transition period due to the change in the year-end. Effectively, one-half of the annual compensation awards described below was awarded to the directors on December 9, 2016 and a full-year’s compensation was awarded at the subsequent annual meeting held in June 2017. Pursuant to the Compensation Policy for Non-Employee Directors, the redemption amount of deferred share units issued will be paid in shares of common stock of the Company on the date a director ceases to be a member of the Board. Annual retainers vest quarterly over approximately one year from the date of grant, contingent upon the individual remaining a director of ImmunoGen as of each vesting date. The number of deferred share units awarded is fixed per the plan on the date of the award. All unvested deferred stock awards will automatically vest immediately prior to the occurrence of a change of control. During the three and six months ended June 30, 2017, the Company recorded approximately $47,000 and $85,000 in compensation expense, respectively, related to deferred share units issued and outstanding under the Company’s Compensation Policy for Non-Employee Directors, compared to $108,00 and $215,000 in compensation expense recorded during the three and six months ended June 30, 2016, respectively. Pursuant to the Compensation Policy for Non-Employee Directors, in January 2017, the Company issued a retiring director 53,248 shares of common stock of the Company to settle outstanding deferred share units. In addition to the deferred share units, the Non-Employee Directors are also entitled to receive a fixed number of stock options determined using the Black-Scholes option pricing model measured on the date of grant, which would be the date of the annual meeting of shareholders. These options vest quarterly over approximately one year from the date of grant. Any new directors will receive a pro-rated award, depending on their date of election to the Board. The directors received a total of 80,000 stock options in November of 2015, 40,000 options in December 2016, and 80,000 options in June 2017, and the related compensation expense for the six months ended June 30, 2017 and 2016 is included in the amounts discussed in the “Stock-Based Compensation” section of footnote B above.

Restructuring Charge

6 Months Ended

Jun. 30, 2017

Restructuring Charge

Restructuring Charge

G. Restructuring Charge

On September 26, 2016, the Board of Directors approved a plan to reengineer the business, resulting in a reduction of the workforce by approximately 17%, or 65 positions, which included the separation of 60 employees at the time of plan approval. Communication of the plan to the impacted employees was substantially completed on September 29, 2016. All of the workforce reduction was completed as of December 31, 2016. As a result of the workforce reduction, in the six months ended December 31, 2016, the Company recorded a restructuring charge totaling $4.4 million related to termination benefits and other related charges, of which $2.8 million was recorded as a one-time termination benefit, and $593,000 recorded as a benefit under an ongoing benefit plan. The related cash payments initiated in October 2016 and were substantially paid out by June 30, 2017. Additionally, approximately 762,000 stock options forfeited in connection with the workforce reduction, and as a result, the Company recorded an approximate $837,000 credit to stock compensation expense in September 2016, which was included in research and development expense and general and administrative expense in that period.

In addition to the termination benefits and other related charges, the Company is seeking to sub-lease 10,281 square feet of unoccupied office space in Waltham that was leased in February 2016. As of September 30, 2016, based on an estimate of the potential time it would take to find a tenant of approximately nine months, the anticipated sub-lease terms, and consideration of the tenant allowance that was given to the Company to build out the space, the Company determined it did not need to record a loss on the sub-lease. The Company also evaluated the balance of the leasehold improvements for potential impairment as of September 30, 2016. In performing the recoverability test, the Company concluded that a substantial portion of the leasehold improvements were not recoverable. The Company recorded an impairment charge of $970,000 related to these assets after comparing the fair value (using probability weighted scenarios with discounted cash flows) to the leasehold improvements’ carrying value, leaving a $193,000 remaining cost basis. As of March 31, 2017, based on further evaluation of the prospects for sub-leasing the space, the Company determined that additional time would be required to find a tenant. Accordingly, the calculation for the potential sub-lease loss was updated and it was determined that the remaining balance of the leasehold improvements was impaired. Also, due to the additional time that is expected to secure a tenant, a lease loss was recorded based on the change in estimate of the sub-lease assumption. The total of these charges was $386,000. There has been no change to this estimate at June 30, 2017.

A summary of activity against the restructuring charge related to the employee terminations during the six-month period ended June 30, 2017 is as follows (in thousands):


	Period from
	December 31, 2016 to
	June 30,
	2017
Balance December 31, 2016	$	1,751
Payments for the period		(1,573)
Balance June 30, 2017	$	178

In September 2016, the Compensation Committee of the Board of Directors approved cash and stock option retention incentive awards for certain remaining eligible employees who continue employment with the Company in order to execute the Company’s strategic priorities. The cash awards will be payable to these employees in either October 2017 or March 2018 based on continued employment and services performed during these periods. Stock option awards covering 750,000 shares granted, that remain outstanding, will vest annually in equal installments over three years from the date of grant, and the related compensation expense for the six months ended June 30, 2017 is included in the amounts discussed in the “Stock-Based Compensation” section of footnote B above.

Commitments and Contingencies

6 Months Ended

Jun. 30, 2017

Commitments and Contingencies

Commitments and Contingencies

H. Commitments and Contingencies

Leases

The Company currently has a lease agreement with CRP/King 830 Winter L.L.C. for the rental of approximately 110,000 square feet of laboratory and office space at 830 Winter Street, Waltham, MA through March 2026. The Company uses this space for its corporate headquarters and other operations. The Company may extend the lease for two additional terms of five years. Pursuant to lease amendments executed in December 2013, April 2014, and December 2015, the Company received construction allowances of approximately $746,000, $1.1 million, and $186,000, respectively, to build out office and lab space to the Company’s specifications. The Company is required to pay certain operating expenses for the leased premises subject to escalation charges for certain expense increases over a base amount.

In February 2016, the Company entered into a lease agreement with PDM 930 Unit, LLC for the rental of 10,281 square feet of additional office space at 930 Winter Street, Waltham, MA through August 31, 2021. The Company received approximately $617,000 as a construction allowance to build out the office space to the Company’s specifications. The Company is required to pay certain operating expenses for the leased premises based on its pro-rata share of such expenses for the entire rentable space of the building. The Company is actively seeking to sub-lease this space.

The Company also leases manufacturing and office space at 333 Providence Highway, Norwood, MA under an agreement through 2018 with an option to extend the lease for an additional term of five years. The Company is required to pay certain operating expenses for the leased premises subject to escalation charges for certain expense increases over a base amount.

Effective April 2013, the Company entered into a lease agreement with River Ridge Limited Partnership for the rental of 7,507 square feet of additional office space at 100 River Ridge Drive, Norwood, MA. The initial term of the lease is for five years and two months commencing in July 2013 with an option for the Company to extend the lease for an additional term of five years. The Company is required to pay certain operating expenses for the leased premises subject to escalation charges for certain expense increases over a base amount. The Company entered into a sublease in December 2014 for this space, effective from January 2015 through July 2018. Due to past payment delinquency, the short span of time remaining on the lease and the estimated amount of time it would take to find another sub-tenant, the remainder of this lease was accrued as a charge in the amount of $169,000 in the first quarter of 2017.

The minimum rental commitments for the Company’s facilities, including real estate taxes and other expenses, for the next five fiscal years and thereafter under the non-cancelable operating lease agreements discussed above are as follows (in thousands):


2017 (six months remaining)	$	3,973
2018		7,736
2019		7,235
2020		7,283
2021		7,107
Thereafter		30,794
Total minimum lease payments	$	64,128

There are no obligations under capital leases as of June 30, 2017, as all of the capital leases were single payment obligations which have all been made.

Collaborations

The Company is contractually obligated to make potential future success-based development, regulatory or sales milestone payments in conjunction with certain collaborative agreements. These payments are contingent upon the occurrence of certain future events and, given the nature of these events, it is unclear when, if ever, the Company may be required to pay such amounts. Further, the timing of any future payment is not reasonably estimable. As of June 30, 2017, the maximum amount that may be payable in the future under the Company’s current collaborative agreements is $160.0 million.

The Company is party to a license agreement covering the manufacture of the antibodies used in certain of product candidates which, under certain circumstances, requires periodic payments once the product reaches a specified stage of clinical development, and royalties on commercial sales of the product. The Company believes that the license agreement, by its terms, does not obligate it to make any further payments thereunder and accordingly, has not accrued a potential payment of £300,000 for one of its product candidates that has reached this stage.

Manufacturing Commitments

As of June 30, 2017, the Company has noncancelable obligations under several agreements related to in-process and future manufacturing of antibody and cytotoxic agents required for clinical supply of the Company’s product candidates totaling $3.3 million, of which $2.0 million will be paid in 2017 and $1.3 million will be paid in 2018.

In February 2017, the Company executed a letter agreement with one of its antibody manufacturers to reserve capacity through calendar 2021. The total commitment over the five-year term of the agreement is €46.2 million, however only €8.4 million euros is noncancelable as of June 30, 2017.

Summary of Significant Accounting Policies (Policies)

6 Months Ended

Jun. 30, 2017

Summary of Significant Accounting Policies

Basis of Presentation

Subsequent Events

Revenue Recognition

At June 30, 2017, the Company had the following two material types of agreements with the parties identified below:

Amgen (two exclusive single-target licenses – one of which has been sublicensed to Oxford BioTherapeutics Ltd.)

Bayer (one exclusive single-target license)

Biotest (one exclusive single-target license)

CytomX (one exclusive single-target license)

Fusion Pharmaceuticals (one exclusive single-target license)

Lilly (three exclusive single-target licenses)

Novartis (five exclusive single-target licenses and one license to two related targets: one target on an exclusive basis and the second target on a non-exclusive basis)

Roche, through its Genentech unit (five exclusive single-target licenses)

Sanofi (five fully-paid, exclusive single-target licenses)

Takeda, through its wholly owned subsidiary, Millennium Pharmaceuticals, Inc. (one exclusive single-target license)

Debiopharm (one exclusive single-target license)

CytomX (one exclusive single-target license)

Takeda, through its wholly owned subsidiary, Millennium Pharmaceuticals, Inc.

There are no performance, cancellation, termination or refund provisions in any of the arrangements that contain material financial consequences to the Company.

Development and Commercialization Licenses

Right‑to‑Test Agreements

Financial Instruments and Concentration of Credit Risk

Cash and Cash Equivalents

Non-cash Investing Activities

Fair Value of Financial Instruments

Level 1 - Quoted prices in active markets for identical assets or liabilities.

Level 3 – Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Fair Value Measurements at June 30, 2017 Using

Quoted Prices in

Significant

Active Markets for

Significant Other

Unobservable

Identical Assets

Observable Inputs

Inputs

Total

(Level 1)

(Level 2)

(Level 3)

Cash equivalents

131,469

—

Fair Value Measurements at December 31, 2016 Using

Quoted Prices in

Significant

Active Markets for

Significant Other

Unobservable

Identical Assets

Observable Inputs

Inputs

Total

(Level 1)

(Level 2)

(Level 3)

Cash equivalents

144,176

—

The fair value of the Company’s cash equivalents is based on quoted prices from active markets.

Unbilled Revenue

Inventory

Inventory at June 30, 2017 and December 31, 2016 is summarized below (in thousands):


	June 30,		December 31,
	2017		2016
Raw materials	$	124	$	357
Work in process		3,358		1,835
Total	$	3,482	$	2,192

Computation of Net Loss per Common Share


	Three Months Ended		Six Months Ended
	June 30,		June 30,
	2017	2016	2017	2016
Options outstanding to purchase common stock and unvested restricted stock	15,588	11,919	15,588	11,919
Common stock equivalents under treasury stock method for options	1,224	232	463	297
Shares issuable upon conversion of convertible notes	23,878	23,878	23,878	23,878
Common stock equivalents under if-converted method for convertible notes	23,878	2,886	23,878	1,443

The Company’s common stock equivalents have not been included in the net loss per share calculation because their effect is anti‑dilutive due to the Company’s net loss position.

Stock-Based Compensation



	Three Months Ended June 30,				Six Months Ended June 30,
	2017		2016		2017		2016
Dividend	None		None		None		None
Volatility	68.17	%	64.13	%	67.10	%	64.06	%
Risk-free interest rate	1.90	%	1.40	%	2.01	%	1.46	%
Expected life (years)	6.0		6.3		6.0		6.3

A summary of option activity under the 2006 and 2016 Plans as of June 30, 2017, and changes during the six month period then ended is presented below (in thousands, except weighted-average data):


		Weighted-
	Number	Average
	of Stock	Exercise
	Options	Price
Outstanding at December 31, 2016	13,679	$	10.70
Granted	1,428	$	2.84
Exercised	(10)		3.30
Forfeited/Canceled	(1,916)	$	10.47
Outstanding at June 30, 2017	13,181	$	9.89



		Number of
		Restricted
		Stock Shares
Unvested at December 31, 2016		199
Awarded		2,253
Vested		(25)
Forfeited		(20)
Unvested at June 30, 2017		2,407

Segment Information

During the six months ended June 30, 2017, the Company continued to operate in one operating segment which is the business of discovery of monoclonal antibody-based anticancer therapeutics.

The percentages of revenues recognized from significant customers of the Company in the six months ended June 30, 2017 and 2016 are included in the following table:


	Three Months Ended				Six Months Ended
	June 30,				June 30,
Collaborative Partner:	2017		2016		2017		2016
Bayer	—	%	—	%	—	%	37	%
CytomX	3	%	10	%	22	%	5	%
Roche	17	%	80	%	21	%	49	%
Sanofi	77	%	—	%	53	%	—	%

There were no other customers of the Company with significant revenues in the six months ended June 30, 2017 and 2016.

Recent Accounting Pronouncements

Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2017

Summary of Significant Accounting Policies

Schedule of assets that are required to be measured at fair value on a recurring basis

Fair Value Measurements at June 30, 2017 Using

Quoted Prices in

Significant

Active Markets for

Significant Other

Unobservable

Identical Assets

Observable Inputs

Inputs

Total

(Level 1)

(Level 2)

(Level 3)

Cash equivalents

131,469

—

Fair Value Measurements at December 31, 2016 Using

Quoted Prices in

Significant

Active Markets for

Significant Other

Unobservable

Identical Assets

Observable Inputs

Inputs

Total

(Level 1)

(Level 2)

(Level 3)

Cash equivalents

144,176

—

Schedule of inventory

Inventory at June 30, 2017 and December 31, 2016 is summarized below (in thousands):


	June 30,		December 31,
	2017		2016
Raw materials	$	124	$	357
Work in process		3,358		1,835
Total	$	3,482	$	2,192

Schedule of common stock equivalents, as calculated in accordance with the treasury-stock method


	Three Months Ended		Six Months Ended
	June 30,		June 30,
	2017	2016	2017	2016
Options outstanding to purchase common stock and unvested restricted stock	15,588	11,919	15,588	11,919
Common stock equivalents under treasury stock method for options	1,224	232	463	297
Shares issuable upon conversion of convertible notes	23,878	23,878	23,878	23,878
Common stock equivalents under if-converted method for convertible notes	23,878	2,886	23,878	1,443

Schedule of assumptions



	Three Months Ended June 30,				Six Months Ended June 30,
	2017		2016		2017		2016
Dividend	None		None		None		None
Volatility	68.17	%	64.13	%	67.10	%	64.06	%
Risk-free interest rate	1.90	%	1.40	%	2.01	%	1.46	%
Expected life (years)	6.0		6.3		6.0		6.3

Summary of stock option activity

A summary of option activity under the 2006 and 2016 Plans as of June 30, 2017, and changes during the six month period then ended is presented below (in thousands, except weighted-average data):


		Weighted-
	Number	Average
	of Stock	Exercise
	Options	Price
Outstanding at December 31, 2016	13,679	$	10.70
Granted	1,428	$	2.84
Exercised	(10)		3.30
Forfeited/Canceled	(1,916)	$	10.47
Outstanding at June 30, 2017	13,181	$	9.89

Summary of restricted stock activity



		Number of
		Restricted
		Stock Shares
Unvested at December 31, 2016		199
Awarded		2,253
Vested		(25)
Forfeited		(20)
Unvested at June 30, 2017		2,407

Schedule of percentage of total revenues recognized from each significant customer


	Three Months Ended				Six Months Ended
	June 30,				June 30,
Collaborative Partner:	2017		2016		2017		2016
Bayer	—	%	—	%	—	%	37	%
CytomX	3	%	10	%	22	%	5	%
Roche	17	%	80	%	21	%	49	%
Sanofi	77	%	—	%	53	%	—	%

Liability Related to Sale of Future Royalties (Tables)

6 Months Ended

Jun. 30, 2017

Schedule of Liability account during the period from the inception of the royalty transaction

The following table shows the activity within the liability account during the six-month period ended June 30, 2017 (in thousands):


	Period from
	December 31, 2016 to
	June 30, 2017
Liability related to sale of future royalties, net — beginning balance	$	184,328
Non-cash Kadcyla royalty revenue		(14,052)
Non-cash interest expense recognized		6,741
Liability related to sale of future royalties, net — ending balance	$	177,017

Restructuring Charge (Tables)

6 Months Ended

Jun. 30, 2017

Restructuring Charge

Schedule activity against the restructuring charge

A summary of activity against the restructuring charge related to the employee terminations during the six-month period ended June 30, 2017 is as follows (in thousands):


	Period from
	December 31, 2016 to
	June 30,
	2017
Balance December 31, 2016	$	1,751
Payments for the period		(1,573)
Balance June 30, 2017	$	178

Commitments and Contingencies (Tables)

6 Months Ended

Jun. 30, 2017

Commitments and Contingencies

Schedule of minimum rental commitments


2017 (six months remaining)	$	3,973
2018		7,736
2019		7,235
2020		7,283
2021		7,107
Thereafter		30,794
Total minimum lease payments	$	64,128

Nature of Business and Plan of Operations (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2016	Dec. 31, 2015
Nature of Business and Plan of Operations
Net loss	$ (8,867)	$ (45,922)	$ (26,212)	$ (77,850)
Accumulated deficit	(958,782)		(958,782)		$ (932,570)
Product revenue			0
Cash and cash equivalents	$ 150,337	$ 245,026	$ 150,337	$ 245,026	$ 159,964	$ 212,283

Summary of Significant Accounting Policies - Revenue (Details)	6 Months Ended
	Jun. 30, 2017 USD ($) item	Jun. 30, 2016 USD ($)	May 24, 2017 USD ($)	Feb. 29, 2016 USD ($)	Dec. 31, 2008 USD ($)	Dec. 31, 2000 USD ($)
Summary of Significant Accounting Policies
Number of types of licensing and development agreements with collaborative partners	2
Difference between the full cost to manufacture and amounts received from collaborators for preclinical and clinical materials \| $	$ 929,000	$ 2,800,000
Number of types of milestone payments under collaborative arrangements	3
Number of quarters in arrear for revenue recognition	1
Minimum
Summary of Significant Accounting Policies
Period to earn royalty payments	10 years
Maximum
Summary of Significant Accounting Policies
Period to earn royalty payments	12 years
Kadcyla \| Minimum
Summary of Significant Accounting Policies
Period to earn royalty payments	10 years
Kadcyla \| Maximum
Summary of Significant Accounting Policies
Period to earn royalty payments	12 years
Amgen
Summary of Significant Accounting Policies
Number of single-target licenses	2
Bayer
Summary of Significant Accounting Policies
Number of single-target licenses	1
Potential milestone payments \| $					$ 170,500,000
Biotest
Summary of Significant Accounting Policies
Number of single-target licenses	1
CytomX
Summary of Significant Accounting Policies
Number of single-target licenses	1
Potential milestone payments \| $				$ 160,000,000
Fusion Pharmaceuticals
Summary of Significant Accounting Policies
Number of single-target licenses	1
Lilly
Summary of Significant Accounting Policies
Number of single-target licenses	3
Novartis
Summary of Significant Accounting Policies
Number of single-target licenses	5
Number of licenses to two related targets	1
Number of related targets	2
Roche
Summary of Significant Accounting Policies
Number of single-target licenses	5
Roche \| Kadcyla
Summary of Significant Accounting Policies
Potential milestone payments \| $						$ 44,000,000
Sanofi
Summary of Significant Accounting Policies
Number of single-target licenses	5
Potential milestone payments \| $	$ 0
Takeda
Summary of Significant Accounting Policies
Number of related targets	1
Oxford BioTherapeutics Ltd Member \| Amgen
Summary of Significant Accounting Policies
Number of single-target licenses	1
Debiopharm
Summary of Significant Accounting Policies
Number of single-target licenses	1
Potential milestone payments \| $			$ 5,000,000
Royalty revenue \| $	$ 0

Summary of Significant Accounting Policies - FinInst (Details)	6 Months Ended	12 Months Ended
	Jun. 30, 2017 USD ($) item	Dec. 31, 2016 USD ($)	Jun. 30, 2016 USD ($)	Dec. 31, 2015 USD ($)
Financial Instruments and Concentration of Credit Risk
Number of financial institutions in the U.S. in which cash and cash equivalents are primarily maintained \| item	3
Marketable securities held by entity	$ 0	$ 0
Cash and Cash Equivalents
Cash and cash equivalents	150,337,000	159,964,000	$ 245,026,000	$ 212,283,000
Noncash Investing Activities
Accrued capital expenditures	$ 14,000	$ 356,000

Summary of Significant Accounting Policies - Fair Value (Details) - USD ($) $ in Thousands	Jun. 30, 2017	Dec. 31, 2016	Jun. 30, 2016
Fair value hierarchy for the Company's financial assets measured at fair value
Interest rate (as a percent)	4.50%		4.50%
Recurring basis
Fair value hierarchy for the Company's financial assets measured at fair value
Cash equivalents	$ 131,469	$ 144,176
Recurring basis \| Quoted Prices in Active Markets for Identical Assets (Level 1)
Fair value hierarchy for the Company's financial assets measured at fair value
Cash equivalents	$ 131,469	144,176
Convertible Notes
Fair value hierarchy for the Company's financial assets measured at fair value
Interest rate (as a percent)	4.50%		4.50%
Convertible Notes \| Significant Other Observable Inputs (Level 2) \| Face Value
Fair value hierarchy for the Company's financial assets measured at fair value
Convertible debt fair value	$ 100,000	100,000
Convertible Notes \| Significant Other Observable Inputs (Level 2) \| Estimated fair value
Fair value hierarchy for the Company's financial assets measured at fair value
Convertible debt fair value	$ 181,500	$ 79,000

Summary of Significant Accounting Policies - Inventory (Details)	3 Months Ended		6 Months Ended
	Jun. 30, 2017 USD ($)	Jun. 30, 2016 USD ($)	Jun. 30, 2017 USD ($) item	Jun. 30, 2016 USD ($)	Dec. 31, 2016 USD ($)
Summary of Significant Accounting Policies
Unbilled partner milestone					$ 5,000,000
Inventory
Raw materials	$ 124,000		$ 124,000		357,000
Work in process	3,358,000		3,358,000		1,835,000
Total	3,482,000		$ 3,482,000		$ 2,192,000
Number of suppliers \| item			2
Minimum supply period of raw materials that is not supported by firm, fixed orders and/or projections from collaborators considered to expense inventory			12 months
Value of excess inventory	0		$ 0
Raw materials inventory write-downs	0	$ 0	403,000	$ 0
Reserve for work in process	$ 0		$ 0

Summary of Significant Accounting Policies - EPS and SBC (Details)				1 Months Ended						2 Months Ended		3 Months Ended		6 Months Ended		9 Months Ended	12 Months Ended
	Jun. 13, 2017 shares	Dec. 09, 2016 shares	Sep. 26, 2016 USD ($) shares	Jun. 30, 2017 USD ($) $ / shares shares	Feb. 28, 2017 $ / shares shares	Dec. 31, 2016 $ / shares shares	Sep. 30, 2016 shares	Aug. 31, 2016 $ / shares shares	Nov. 30, 2015 shares	Sep. 30, 2016 item	Dec. 31, 2015	Jun. 30, 2017 USD ($) item $ / shares shares	Jun. 30, 2016 USD ($) item $ / shares shares	Jun. 30, 2017 USD ($) employee item $ / shares shares	Jun. 30, 2016 USD ($) item $ / shares shares	Jun. 30, 2017 USD ($) item $ / shares shares	Dec. 31, 2016 $ / shares shares
Computation of Net Loss per Common Share
Options outstanding to purchase common stock and unvested restricted stock												15,588,000	11,919,000	15,588,000	11,919,000
Common stock equivalents under treasury stock method for options (in shares)												1,224,000	232,000	463,000	297,000
Shares issuable upon conversion of convertible notes (in shares) \| item												23,878	23,878	23,878	23,878
Common stock equivalents under if-converted method for convertible notes (in shares)												23,878,000	2,886,000	23,878,000	1,443,000
Additional disclosure for options
Cash received for exercise of stock options \| $														$ 32,000	$ 370,000
Stock compensation expense (reduction) \| $												$ 3,100,000	$ 4,500,000	5,700,000	11,600,000
Estimated fair value of unvested employee awards, net of estimated forfeitures \| $				$ 15,000,000								$ 15,000,000		$ 15,000,000		$ 15,000,000
Weighted average vesting period of unvested employee awards														2 years
Chief Executive Officer
Additional disclosure for options
Stock compensation cost due to modification \| $															$ 3,100,000
Stock options
Weighted-average assumptions used to estimate the fair value of each stock option
Dividend (as a percent)												0.00%	0.00%	0.00%	0.00%
Volatility (as a percent)												68.17%	64.13%	67.10%	64.06%
Risk-free interest rate (as a percent)												1.90%	1.40%	2.01%	1.46%
Expected life												6 years	6 years 3 months 18 days	6 years	6 years 3 months 18 days
Weighted-average grant date fair value (in dollars per share) \| $ / shares												$ 2.86	$ 3.44	$ 1.75	$ 4.10
Number of Stock Options
Outstanding at the beginning of the period (in shares)														13,679
Granted (in shares)														1,428
Exercised (in shares)														(10)
Forfeited/Canceled (in shares)														(1,916)
Outstanding at the end of the period (in shares)				13,181		13,679						13,181		13,181		13,181	13,679
Weighted-Average Exercise Price
Outstanding at the beginning of the period (in dollars per share) \| $ / shares														$ 10.70
Granted (in dollars per share) \| $ / shares														2.84
Exercised (in dollars per share) \| $ / shares														3.30
Forfeited/Canceled (in dollars per share) \| $ / shares														10.47
Outstanding at the end of the period (in dollars per share) \| $ / shares				$ 9.89		$ 10.70						$ 9.89		$ 9.89		$ 9.89	$ 10.70
Additional disclosure for options
Cash received for exercise of stock options \| $															$ 32,000
Restricted stock
Stock-Based Compensation
Exercise period										5 years						5 years
Number of equal installments restrictions lapse \| item										3						3
Number of Restricted Stock
Unvested at the beginning of the period (in shares)														199,000
Awarded (in shares)														2,253,000
Vested (in shares)														(25,000)
Forfeited (in shares)														(20,000)
Unvested at the end of the period (in shares)				2,407,000		199,000						2,407,000		2,407,000		2,407,000	199,000
Weighted-Average Exercise Price
Awarded (in dollars per share) \| $ / shares								$ 3.15
Additional disclosure for options
Stock compensation expense (reduction) \| $														$ 0
Restricted stock \| Officers
Number of Restricted Stock
Awarded (in shares)				239,000	529,830			117,800
Weighted-Average Exercise Price
Awarded (in dollars per share) \| $ / shares				$ 4.71	$ 2.47			$ 3.15
Compensation Policy for Non-Employee Directors
Number of Stock Options
Granted (in shares)				80,000
Additional disclosure for options
Stock compensation expense (reduction) \| $												$ 47,000	$ 10,800	$ 85,000	$ 215,000
Compensation Policy for Non-Employee Directors \| Stock options
Stock-Based Compensation
Vesting period											1 year			1 year			1 year
Number of Stock Options
Granted (in shares)						40,000			80,000
Compensation Policy for Non-Employee Directors \| Deferred share units
Stock-Based Compensation
Vesting period		1 year
2016 Plan
Computation of Net Loss per Common Share
Common stock equivalents under treasury stock method for options (in shares)		14,250,000
Stock-Based Compensation
Number of employee share-based compensation plans \| employee														1
Additional shares authorized for issuance (in shares)	1,000,000
Common stock authorized for issuance (in shares)		5,500,000
2016 Plan \| Stock options
Weighted-average assumptions used to estimate the fair value of each stock option
Number of group of awards for which expected term is calculated for and applied \| item														1
2016 Plan \| Stock options \| Maximum
Stock-Based Compensation
Vesting period														4 years
Exercise period														10 years
Workforce reduction
Stock-Based Compensation
Vesting period							3 years
Number of Stock Options
Granted (in shares)							750,000
Workforce reduction \| Stock options
Number of Stock Options
Forfeited/Canceled (in shares)			(762,000)
Additional disclosure for options
Stock compensation expense (reduction) \| $			$ 837,000

Summary of Significant Accounting Policies - Segments (Details) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017 USD ($)	Jun. 30, 2016	Jun. 30, 2017 USD ($) item	Jun. 30, 2016	Dec. 31, 2016 USD ($)
Segment Information
Number of operating segments \| item			1
Recent Accounting Pronouncements
Prepaid and other current assets	$ 4,758		$ 4,758		$ 5,386
Other assets	$ 3,148		$ 3,148		$ 3,020
Bayer \| Revenues percentage \| Customer concentration
Segment Information
Percentages of revenue recognized				37.00%
CytomX \| Revenues percentage \| Customer concentration
Segment Information
Percentages of revenue recognized	3.00%	10.00%	22.00%	5.00%
Roche \| Revenues percentage \| Customer concentration
Segment Information
Percentages of revenue recognized	17.00%	80.00%	21.00%	49.00%
Sanofi \| Revenues percentage \| Customer concentration
Segment Information
Percentages of revenue recognized	77.00%		53.00%
Maximum \| Accounting Standards Update 2014-09
Recent Accounting Pronouncements
Number of contracts requiring evaluation \| item			20
Federal \| New accounting pronouncement \| Accounting Standards Update 2016-09
Recent Accounting Pronouncements
Net deferred tax assets	$ 9,200		$ 9,200
Valuation allowance	9,200		9,200
State \| New accounting pronouncement \| Accounting Standards Update 2016-09
Recent Accounting Pronouncements
Net deferred tax assets	1,200		1,200
Valuation allowance	$ 1,200		$ 1,200

Agreements - Roche (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended		12 Months Ended	210 Months Ended
Agreements - Roche (Details) - USD ($) $ in Thousands	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2000	Jun. 30, 2017
Collaborative Agreements disclosures
Non-cash royalty revenue related to sale of future royalties	$ 6,439	$ 5,944	$ 14,052	$ 13,324
Roche \| Kadcyla
Collaborative Agreements disclosures
Payments received under collaboration agreement					$ 2,000
Potential milestone payments					$ 44,000
Period in arrears to receive royalty reports and payments related to sales of Kadcyla					3 months
Non-cash royalty revenue related to sale of future royalties			14,100	$ 13,300
Roche \| Kadcyla \| Development milestones
Collaborative Agreements disclosures
Payments received under collaboration agreement						$ 13,500
Potential milestone payments					$ 13,500
Roche \| Kadcyla \| Regulatory milestones
Collaborative Agreements disclosures
Payments received under collaboration agreement						20,500
Potential milestone payments	$ 5,000		$ 5,000		$ 30,500	$ 5,000

Agreements - Sanofi (Details) $ in Thousands		3 Months Ended		6 Months Ended
Agreements - Sanofi (Details) $ in Thousands	May 30, 2017 USD ($) item	Jun. 30, 2017 USD ($)	Jun. 30, 2016 USD ($)	Jun. 30, 2017 USD ($)	Jun. 30, 2016 USD ($)
Collaborative Agreements disclosures
License and milestone fees		$ 31,080	$ 76	$ 49,810	$ 10,153
Sanofi
Collaborative Agreements disclosures
Number of compounds \| item	4
Payments received under collaboration agreement	$ 30,000
License and milestone fees		$ 30,000		$ 30,000

Agreements - Bayer (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended	108 Months Ended
Agreements - Bayer (Details) - USD ($) $ in Thousands	Jan. 31, 2016	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2008	Dec. 31, 2016
Collaborative Agreements disclosures
Amount of arrangement consideration included in license and milestone fees		$ 31,080	$ 76	$ 49,810	$ 10,153
Bayer
Collaborative Agreements disclosures
Payments received under collaboration agreement				13,000		$ 4,000	$ 13,000
Potential milestone payments						$ 170,500
Bayer \| Minimum
Collaborative Agreements disclosures
Percentage of royalty payments						4.00%
Bayer \| Maximum
Collaborative Agreements disclosures
Percentage of royalty payments						7.00%
Bayer \| Development milestones
Collaborative Agreements disclosures
Potential milestone payments		$ 2,000		$ 2,000		$ 16,000
Bayer \| Phase 2 clinical trial
Collaborative Agreements disclosures
Payments received under collaboration agreement	$ 10,000
Bayer \| Regulatory milestones
Collaborative Agreements disclosures
Potential milestone payments						44,500
Bayer \| Sales milestones
Collaborative Agreements disclosures
Potential milestone payments						$ 110,000

Agreements - CytomX (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		6 Months Ended
Agreements - CytomX (Details) - USD ($) $ in Thousands	Feb. 29, 2016	Jan. 31, 2014	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Collaborative Agreements disclosures
License and milestone fees			$ 31,080	$ 76	$ 49,810	$ 10,153
Costs related to the research and development services			35,319	$ 38,652	68,207	$ 74,746
CytomX
Collaborative Agreements disclosures
Payments received under collaboration agreement	$ 13,000	$ 0
License and milestone fees					12,700
Potential milestone payments	160,000
CytomX \| Development milestones
Collaborative Agreements disclosures
Potential milestone payments	10,000
CytomX \| Phase 1 clinical trial
Collaborative Agreements disclosures
License and milestone fees			1,000		1,000
CytomX \| Phase 2 clinical trial
Collaborative Agreements disclosures
Potential milestone payments			$ 3,000		$ 3,000
CytomX \| Regulatory milestones
Collaborative Agreements disclosures
Potential milestone payments	50,000
CytomX \| Sales milestones
Collaborative Agreements disclosures
Potential milestone payments	$ 100,000

Agreements - Debiopharm (Details) - USD ($)		3 Months Ended		6 Months Ended
Agreements - Debiopharm (Details) - USD ($)	May 24, 2017	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Collaborative Agreements disclosures
License and milestone fees		$ 31,080,000	$ 76,000	$ 49,810,000	$ 10,153,000
Research and development support		902,000	$ 1,335,000	2,380,000	$ 2,394,000
Debiopharm
Collaborative Agreements disclosures
Payments received under collaboration agreement	$ 25,000,000
Potential milestone payments	5,000,000
Fair value of consideration for services provided	30,000,000
License and milestone fees	29,700,000
Research and development support	300,000
Remaining arrangement consideration to be recognized as license revenue		$ 25,000,000		$ 25,000,000
Debiopharm \| Phase 3 Clinical Trial
Collaborative Agreements disclosures
Potential milestone payments	$ 25,000,000

Convertible 4.5% Senior Notes (Details)	1 Months Ended	3 Months Ended		6 Months Ended
Convertible 4.5% Senior Notes (Details)	Jun. 30, 2016 USD ($) item $ / shares	Jun. 30, 2017 USD ($)	Jun. 30, 2016 USD ($) $ / shares	Jun. 30, 2017 USD ($)	Jun. 30, 2016 USD ($) $ / shares
Convertible debt
Interest rate (as a percent)	4.50%	4.50%	4.50%	4.50%	4.50%
Proceeds from issuance of debt					$ 96,608,000
Issuance of debt transaction costs					3,392,000
Interest expense		$ 1,125,000	$ 138,000	$ 2,250,000	$ 138,000
Convertible Notes
Convertible debt
Interest rate (as a percent)	4.50%	4.50%	4.50%	4.50%	4.50%
Principal amount of debt	$ 100,000,000		$ 100,000,000		$ 100,000,000
Proceeds from issuance of debt	96,600,000
Issuance of debt transaction costs	3,400,000
Interest expense				$ 2,300,000	138,000
Principal amount of debt for conversion calculations	$ 1,000		$ 1,000		$ 1,000
Ratio issued upon conversion	238.7775
Initial conversion price (in dollars per share) \| $ / shares	$ 4.19		$ 4.19		$ 4.19
Principal amount of notes to be repurchased under certain conditions (as a percent)	100.00%
Principal amount of notes to be repurchased upon default (as a percent)	100.00%
Additional interest for reporting requirement failure (as a percent)	0.50%
Default cure period	90 days
Additional interest for restricted event (as a percent)	0.50%
Number of additional interest rate percentage penalty circumstances \| item	2
Maximum additional interest rate (as a percent)	0.50%

Liability Related to Sale of Future Royalties (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		6 Months Ended		27 Months Ended
	Apr. 30, 2015	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017
Roll forward
Non-cash Kadcyla royalty revenue		$ (6,439)	$ (5,944)	$ (14,052)	$ (13,324)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes		3,501	$ 4,956	7,076	$ 9,928
Kadcyla
Liability Related to Sale of Future Royalties
Percentage of royalty payments if applicable threshold is met	85.00%
Kadcyla \| IRH
Liability Related to Sale of Future Royalties
Percentage of royalty payments	100.00%
Royalty revenue	$ 235,000
Royalties on net sales of Kadcyla when royalties to the purchaser reach a specified milestone	$ 260,000
Percentage of royalty payments if applicable threshold is met	15.00%
Proceeds from sale of future royalties - net	$ 200,000
Transaction costs for royalty agreements	$ 5,900
Roll forward
Liability related to sale of future royalties, net — beginning balance				184,328
Non-cash Kadcyla royalty revenue				(14,052)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes				6,741
Liability related to sale of future royalties, net — ending balance		$ 177,017		$ 177,017		$ 177,017
Effective annual interest rate						7.70%

Capital Stock (Details) - USD ($)		1 Months Ended					2 Months Ended	3 Months Ended		6 Months Ended		12 Months Ended
Capital Stock (Details) - USD ($)	Dec. 09, 2016	Jun. 30, 2017	Jan. 31, 2017	Dec. 31, 2016	Nov. 30, 2015	Jun. 30, 2004	Dec. 31, 2015	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2016
Stock-based compensation disclosure
Stock compensation expense (reduction)								$ 3,100,000	$ 4,500,000	$ 5,700,000	$ 11,600,000
Stock options
Stock-based compensation disclosure
Stock options granted to directors (in shares)										1,428
2001 Director Plan
Stock-based compensation disclosure
Stock compensation expense (reduction)								21,000	(35,000)	$ 32,000	(67,000)
Stock units issued (in shares)						0
Compensation Policy for Non-Employee Directors
Stock-based compensation disclosure
Stock compensation expense (reduction)								$ 47,000	$ 10,800	$ 85,000	$ 215,000
Stock options granted to directors (in shares)		80,000
Compensation Policy for Non-Employee Directors \| Stock options
Stock-based compensation disclosure
Vesting period							1 year			1 year		1 year
Stock options granted to directors (in shares)				40,000	80,000
Compensation Policy for Non-Employee Directors \| Deferred share units
Stock-based compensation disclosure
Stock units issued (in shares)			53,248
Shares issued on annual basis (as a percent)	50.00%
Vesting period	1 year

Restructuring Charge (Details)		1 Months Ended	3 Months Ended		6 Months Ended
Restructuring Charge (Details)	Sep. 26, 2016 USD ($) item shares	Sep. 30, 2016 shares	Jun. 30, 2017 USD ($)	Jun. 30, 2016 USD ($)	Jun. 30, 2017 USD ($) shares	Dec. 31, 2016 USD ($)	Jun. 30, 2016 USD ($)	Feb. 29, 2016 USD ($) ft²
Restructuring
Restructuring charges					$ 386,000
Stock compensation expense (reduction)			$ 3,100,000	$ 4,500,000	5,700,000		$ 11,600,000
Construction allowance			5,521,000		5,521,000	$ 5,914,000
Restructuring Reserve
Initial charge related to employee benefits, Beginning Balance					1,751,000
Payments for the period					(1,573,000)
Balance at the End of the year			$ 178,000		178,000	1,751,000
Workforce reduction
Restructuring
Approximate positions to be eliminated (as a percent)	17.00%
Approximate positions to be eliminated \| item	65
Approximate current positions to be eliminated \| item	60
Restructuring charges						4,400,000
One-time termination benefit						2,800,000
Benefit plan severance cost						$ 593,000
Granted (in shares) \| shares		750,000
Vesting period		3 years
930 Winter Street, Walham, MA
Restructuring
Area of space leased \| ft²								10,281
Construction allowance								$ 617,000
930 Winter Street, Walham, MA \| Lease
Restructuring
Area of space leased \| ft²								10,281
Estimated period to sub-lease		9 months
Leasehold impairment charge	$ 970,000				$ 386,000
Leasehold improvement cost	$ 193,000
Stock options
Restructuring
Forfeited (in shares) \| shares					1,916
Granted (in shares) \| shares					1,428
Stock options \| Workforce reduction
Restructuring
Forfeited (in shares) \| shares	762,000
Stock compensation expense (reduction)	$ 837,000

Commitments and Contingencies (Details) € in Millions	1 Months Ended		3 Months Ended	6 Months Ended
Commitments and Contingencies (Details) € in Millions	Feb. 28, 2017 EUR (€)	Apr. 30, 2013 ft²	Mar. 31, 2017 USD ($)	Jun. 30, 2017 GBP (£) ft² item	Jun. 30, 2017 USD ($) ft²	Dec. 31, 2016 USD ($)	Feb. 29, 2016 USD ($) ft²	Dec. 31, 2015 USD ($)	Apr. 30, 2014 USD ($)	Dec. 31, 2013 USD ($)
Operating leases
Construction allowance					$ 5,521,000	$ 5,914,000
Minimum rental commitments under the non-cancelable operating lease agreements
2017 (six months remaining)					3,973,000
2018					7,736,000
2019					7,235,000
2020					7,283,000
2021					7,107,000
Thereafter					30,794,000
Total minimum lease payments					64,128,000
Obligations under capital leases					0
Collaborations and Licenses
Potential milestone payable					160,000,000
Obligation to make payment to vendor for certain contractual services \| £				£ 300,000
Manufacturing Commitments
Collaborations and Licenses
Obligation to make payment to vendor for certain contractual services \| €	€ 46.2
Other commitment					3,300,000
Due 2017					2,000,000
Due 2018					$ 1,300,000
Term of agreement	5 years
Noncancelable commitment \| €	€ 8.4
830 Winter Street, Waltham, MA
Operating leases
Area of space leased \| ft²				110,000	110,000
Number of additional terms for which lease agreement can be extended \| item				2
Operating lease term extension period				5 years
Construction allowance								$ 186,000	$ 1,100,000	$ 746,000
930 Winter Street, Walham, MA
Operating leases
Area of space leased \| ft²							10,281
Construction allowance							$ 617,000
333 Providence Hwy, Norwood MA
Operating leases
Operating lease term extension period				5 years
100 River Ridge Drive, Norwood, MA
Operating leases
Area of space leased \| ft²		7,507
Operating lease term extension period		5 years
Operating lease term period		5 years 2 months
Facilities rent expense, net of sublease income			$ 169,000